MEL-TARGET

Project 1: Development and validation of tools that can predict cell death induced by 2nd generation TRAIL receptor ligands

Location: University of Stuttgart , Germany

Principal Investigator: Prof Markus Rehm

Collaborators: Prof Dagmar Kulms (Tech. University of Dresden, TUD)

                     Prof Roland Kontermann (University of Stuttgart, USTUTT)


Project 2: Mechanistic insight into the consequences of sublethal IZI1551 doses to prevent unwanted proliferation and migration of melanoma metastases

Location: Technical University of Dresden , Germany

Principal Investigator: Prof Dagmar Kulms

Collaborators: Prof Thomas Sauter (University of Luxembourg, UL)

                     Prof Roland Kontermann (University of Stuttgart, USTUTT)


Projects 3: Establishing a multi-scale modelling environment for pro-survival and proliferation signalling to understand melanoma growth arrest and recurrence

Location: University of Luxembourg , Luxembourg

Principal Investigator: Prof Thomas Sauter

Collaborators: Prof Dagmar Kulms (Technical University of Dresden, TUD)

Prof Zvia Agur (Optimata Ltd, OPTI)


Project 4: Understanding the impact of necroptosis inhibitors on cell death resistance of malignant melanoma

Location: University of Stuttgart , Germany

Principal Investigator: Prof Markus Rehm (Royal College of Surgeons in Ireland, RCSI)

Collaborators: Prof Leonidas Alexopoulos (ProtATonce, PAO)


Project 5: Predicting susceptibility to mutation specific targeted drugs using quantitative modeling in malignant melanoma

Location: Technical University of Dresden , Germany

Principal Investigator: Prof Dagmar Kulms

Collaborators: Prof Walter Kolch (University College Dublin, UCD)

Dr Jorg Eberhardt (Novartis Pharma GmbH, NOV)


Project 6: Systems analysis of immunogenic cell death (ICD) and the potential of ICD signatures as prognostic or predictive markers of melanoma responsiveness

Location: University of Leuven , Belgium

Principal Investigator: Prof Patrizia Agostinis

Collaborators: Prof Thomas Sauter (University of Luxembourg, UL)

Dr Jorg Eberhardt (Novartis Pharma GmbH, NOV)


Project 7: Identification of candidate network structures for the quantitative dynamical modelling of MM-141-induced melanoma-specific signalling

Location: University of Luxembourg , Luxembourg

Principal Investigator: Prof Thomas Sauter

Collaborators: Prof Walter Kolch (University College Dublin, UCD)

Dr Birgit Schoeberl (Merrimack Pharmaceuticals, MM)


Project 8: Identifying phopshoproteome and cytokine patterns indicative of responsiveness to dasatinib-based single and combination treatments

Location: ProtATonce , Greece

Principal Investigator: Prof Leonidas Alexopoulos

Collaborators: Prof Markus Rehm (Royal College of Surgeons in Ireland, RCSI)

 


 

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