Conference Contributions

2018

Posters:

Bodemeyer V, De Zio D & Cecconi F Ambra1 based signalling in melanoma development. European Workshop on Cell Death, Fiuggi, Italy – 6-11/05/2018.

Bodemeyer V, De Zio D & Cecconi F Ambra1 based signalling in melanoma development. Center for Autophagy, Recycling and Disease Follow-up Meeting, Copenhagen, Denmark – 19/06/2018.

Bodemeyer V, Di Leo L, Maiani E, Claps G, Robert C, Guldberg P, Cecconi F & De Zio D The tumor suppressor role of AMBRA1 in melanoma. Nordic Autophagy Society Conference, Riga, Latvia – 31/08/2018.

Bodemeyer V, Di Leo L, Maiani E, Claps G, Robert C, Guldberg P, Cecconi F & De Zio D The tumor suppressor role of AMBRA1 in melanoma. Nordic Melanoma Meeting, Copenhagen – 05/09/2018.

Bodemeyer V, Di Leo L, Maiani E, Claps G, Robert C, Guldberg P, Cecconi F & De Zio D The tumor suppressor role of AMBRA1 in melanoma. Society for Melanoma Research Congress, Manchester – 26/10/2018.

Bosisio FM High dimensional in situ single-cell analysis of tumor-infiltrating lymphocytes in primary melanoma using multiplex staining on tissue sections. Society of Melanoma Research Congress, Manchester – 25-27/10/2018.

Del Mistro G, De Landtsheer S, Lucarelli P, Zinoveva A, Sauter T, Kontermann R, Beissert S, Kulms D System-based analysis re-identifies TRAIL-agonistic antibodies as a promising melanoma treatment option. European Workshop on Cell Death, Fiuggi, Italy – 6-11/05/2018.

Del Mistro G, De Landtsheer S, Lucarelli P, Müller I, Zinoveva A, Hutt M, Siegemund M, Kontermann RE, Beissert S, Sauter T, Kulms D Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma. 26th ECDO Conference, St Petersburg, Russia – 10-12/10/2018

Frangez Z The role of autophagy and its related genes in melanoma progression. Swiss Apoptosis Meeting 2018, Bern, Switzerland – 13/09/2018.

Frangez Z The role of autophagy and its related genes in melanoma progression. 16th International Summer School, University of Bern – 29/07/2018.

Müller I, Strozyk E, Schindler S, Del Mistro G, Beissert S, Zarni Oo H, Sauter T, Lucarelli P, Raeth S, Hausser A, Al Nakouzi N, Zhai B, Fazli L, Gleave M, Liu H, Simon HU, Walczak H, Green DR, Daugaard M, Kulms D Cancer cells employ nuclear caspase-8 to overcome the p53-dependent G2/M checkpoint. 26th ECDO Conference, St Petersburg, Russia – 10-12/10/2018.

Müller I, Strozyk E, Schindler S, Del Mistro G, Beissert S, Zarni Oo H, Sauter T, Lucarelli P, Raeth S, Hausser A, Al Nakouzi N, Zhai B, Fazli L, Gleave M, Liu H, Simon HU, Walczak H, Green DR, Daugaard M, Kulms D Cancer cells employ nuclear caspase-8 to overcome the p53-dependent G2/M checkpoint. European Workshop on Cell Death, Fiuggi, Italy – 6-11/05/2018.

Müller I, Strozyk E, Schindler S, Del Mistro G, Beissert S, Zarni Oo H, Sauter T, Lucarelli P, Raeth S, Hausser A, Al Nakouzi N, Zhai B, Fazli L, Gleave M, Liu H, Simon HU, Walczak H, Green DR, Daugaard M, Kulms D Cancer cells employ nuclear caspase-8 to overcome the p53-dependent G2/M checkpoint. Keystone Symposia on Cell Death and Inflammation, Breckenridge, Colorado, USA – January/2018.

Rožanc J, Sakellaropoulos T, Pliaka V, Antoranz A, Guttà C, Podder B, Vetma V, Sauter T, Rehm M, Alexopoulos LG Predicting the cell death responsiveness and sensitization of melanoma cells to MEK inhibitor trametinib. European Workshop on Cell Death, Fiuggi, Italy – 6-11/05/2018.

talks:

Agostinis P Harnessing immunogenic cell death in cancer therapy; molecular mechanisms and therapeutic applications. 26th ECDO Conference, St Petersburg, Russia – 10-12/10/2018.

Agostinis P ER stress and immunogenic cell death: a matter of contcat sites? EMBO Workshop on membrane contact sites in health and disease, Arosa, Switzerland – 21-25/09/2018.

Agostinis P Immunogenic cancer cell death in cancer therapy. Invited speaker at University of Geneva – 05/09/2018.

Agostinis P Harnessing immunogenic cell death for immunotherapy against cancer. Invited speaker at the University of Luxembourg – 26/04/2018.

Agostinis P Harnessing immunogenic cell death in cancer therapy. VIB-Lecture KU Leuven – 27/02/2018.

Bosisio FM High dimensional in situ single-cell analysis of tumor-infiltrating lymphocytes in primary melanoma using multiplex staining on tissue sections. EORTC Melanoma Group meeting, Palma de Mallorca – 04-06/10/208.

Cecconi F, Strappazzon F, Di Rita A, D’Acunzo P The E3 ligase HUWE1 promotes PINK1/PARKIN-independent mitophagy by regulating AMBRA1 activation via IKKα. Cell Symposium on “Multifaceted mitochondria”, San Diego, CA, USA – 05/06/2018.

Cecconi F Autophagy and autophagy-related molecules in cell stress and survival. From Stress Response to Tissue Development and Regeneration, Pavia, Italy – 28-29/09/2018.

Del Mistro G, Lucarelli P, Müller I, De Landtsheer S, Zinoveva A, Hutt M, Siegemund M, Kontermann RE, Beissert S, Sauter T, Kulms D Systemic network analysis identifies XIAP and IκBα as potential drug targets in TRAIL resistant BRAF mutated melanoma. E:Med Metting on Systems Medicine 2018, Berlin, Germany – September 2018

De Zio D The tumor suppressor role of AMBRA1 in melanoma. Nordic Autophagy Society Conference, Riga, Latvia – 31/08/2018.

De Zio D The tumor suppressor role of AMBRA1 in melanoma. Center Meeting of the Danish Cancer Society – 24/10/2018.

Frangez Z The role of autophagy and its related genes in melanoma progression. Galderma R&D Sophia-Antipolis– 25/04/2018.

Khorsand F, Rukhlenko O, Fitzgibbon C, Chiquero-Leon E, Liu Z, Rauch N, Panada E, Lee S, Rozanc J, Alexopoulos L, Gómez-Coca S, Rosta E, Kholodenko B, Kolch W & Rauch J Tackling acquired resistance mechanisms in malignant melanoma. 5. Virtual Physiological Human conference VPH2018, Zaragoza, Spain – 05/09/2018.

Müller I, Del Mistro G, Praetorius C, Meier F, Lucarelli P, Sauter T, Siegemund M, Kontermann RE, Rehm M, Kulms D Predicting sensitivity of malignant melanoma to combination therapies by network modelling. E:Med Metting on Systems Medicine 2017, Göttingen, Germany – November/2018.

Müller I, Strozyk E, Schindler S, Del Mistro G, Beissert S, Zarni Oo H, Sauter T, Lucarelli P, Raeth S, Hausser A, Al Nakouzi N, Zhai B, Fazli L, Gleave M, Liu H, Simon HU, Walczak H, Green DR, Daugaard M, Kulms D Cancer cells employ nuclear caspase-8 to overcome the p53-dependent G2/M checkpoint. Swiss Apoptosis Meeting, Bern, Switzerland – September 2018.

Müller I, Strozyk E, Schindler S, Del Mistro G, Beissert S, Zarni Oo H, Sauter T, Lucarelli P, Raeth S, Hausser A, Al Nakouzi N, Zhai B, Fazli L, Gleave M, Liu H, Simon HU, Walczak H, Green DR, Daugaard M, Kulms D Cancer cells employ nuclear caspase-8 to overcome the p53-dependent G2/M checkpoint. Gordon Conference on Cell Death, Newry, Maine, USA – August/2018.

Rauch J Tackling acquired resistance mechanisms in malignant melanoma. 8 Fortbildung des Instituts für Dermatopathologie Hannover, Dermapathologie Hannover, Hannover, Germany – 10/01/2018

Rehm M Cell death control – from mechanisms to applications. Seminar Series of the Cancer Research Unit, Univ. of Montpellier, France, September 2018.

Rehm M Modelling cancer cell death – from mechanistic insight to systems-based patient prognosis. 3rd OpenMultiMed Training School (Multi-scale and Multi-level Modelling Methodologies in Biomedicine), Erlangen, Germany, February 2018.

Rehm M Cell death control – from mechanisms to applications. Seminar Series of the Fraunhofer institute for production technology and automatization, Stuttgart, Germany, January 2018.

Rufo N Perk and IRE1a of the UPR contribute to immunogenic cancer cell death. 26th ECDO Conference, St Petersburg, Russia – 10-12/10/2018.

Rufo N Systems Biology of Immunogenic Cell Death (ICD) in Melanoma. European Workshop on Cell Death, Fiuggi, Italy – 6-11/05/2018.

Simon HU Eosinophil cytolysis requires the RIPK3-MLKL signaling pathway which is counter-regulated by autophagy. 8th Cell Death & Disease Symposium on Precision Medicine and Cell Therapy, Changzhou, China – 04-06/11/2017.

Tsur N, Kogan Y, Avizov-Khodak E, Vaeth D, Vogler N, Utikal J, Lotem M & Agur Z. Predicting response to pembrolizumab in metastatic melanoma by a personalized mathematical model. Seminar at Optimata & IMBM and external participants.

Van den Oord JJ Immune response in melanoma. Invited talk at University of Brescia, Italy – 15/10/2018.

Van den Oord JJ Analysis of brisk and non-brisk TILs in melanoma using multiplex immunostaining. Meeting of the International Melanoma Pathology Study Group (IMPSG), Manchester – 23-24/10/2018.

2017

Posters:

Albrecht M, Sciumé G, Kogan Y, Agur Z, Kulms D & Sauter T Establishing a multi-scale modelling environment for pro-survival and proliferation signalling to understand melanoma growth arrest and recurrence. PhD days (University of Luxembourg) – December 2017.

Bosisio FM, Wouters J, Stas M, Bolognesi, M, Scalia, C & van den Oord J In situ evaluation of markers of activation and inhibition of Tumor Infiltrating Lymphocytes (TILs) after microdissection: remarks to the current morphologic classification of the “TILs patterns”. Irish association for Cancer Research Annual Meeting, 22-25 February 2017.

Bosisio FM, Rhaman A, Peralbo E, Elliott L, Blanco A, Ryan E, van den Oord J & Gallagher W Investigation on the effects of melanin exposure on macrophages: a preliminary study. International Congress of the ESP, 02-06 September 2017.

Chiquero-Leon E, Rauch N, Romano D, Rauch J, Kolch W Regulation of the human Hippo/MST2 pathway in drug-mediated resistant melanoma. UCD Computational and Molecular Biology PhD Symposium 2017, Ireland – 30/11/2017

Chiquero-Leon E, Lefeivre T, Fitzgibbon C, Rauch N, Frederick D, Flaherty K , Aura C, Rahman A, Gallagher W, Rauch J & Kolch W Regulation of the human Hippo/MST2 pathway in Raf inhibitor mediated resistant melanoma. UCD Conway Festival of Research 13 September 2017.

De Landtsheer S, Trairatphisan P, Lucarelli P & Sauter T FALCON: A Fast Algorithm for the Contextualisation of Logical Network Models. SBHD17 Systems Biology of Human Diseases, Heidelberg, 27 July 2017.

Del Mistro G & Kulms D Impact of sublethal drug doses on melanoma cell behavior and tumor relapse. 11th CRTD Summer Conference on Regenerative Medicine, 26 May 2017

Guttà C, Vetma V, Praetorius C, Kontermann R, Kulms D, Rehm M Data driven modeling predicts responsiveness to TRAIL/Smac mimetic combinations in malignant melanoma. 25th European Cell Death Organization (ECDO) conference on ‘Cell Death and Immunity in Disease: from molecules to translational medicine, 27-29 September 2017.

Podder B & Rehm M Studying necroptosis competency in malignant melanoma. 25th European Cell Death Organization (ECDO) conference on ‘Cell Death and Immunity in Disease: from molecules to translational medicine, 27-29 September 2017.

Rufo N, Garg AD, Finotello F, Trajanoski Z, Sinkkonen L, Sauter T & Agostinis P. Systems Biology of Immunogenic Cell Death (ICD) in Melanoma. KU Leuven Oncoforum 09 June 2017.

Rufo N, Garg AD, Finotello F, Trajanoski Z, Sinkkonen L, Sauter T & Agostinis P. Systems Biology of Immunogenic Cell Death (ICD) in Melanoma. 25th Conference of the European Cell Death Organization (ECDO), 27-29 September 2017.

Silva R, Rahman A, Bosisio F & Gallagher W UHFR1 as a prognostic biomarker in malignant melanoma. UCD Conway Festival, 13-14 September 2017.

Published abstracts:

Niessner H, Wanke I, Sinnberg T, Mai M, Praetorius C, Garbe C, Kulms D, Beissert S, Westphal D, Meier F (2017) The combination of BRAFi and MEKi: A treatment option for BRAF WT patients? Exp Dermatol 26: doi: 10.1111/exd.13280.

Seip K, Haselager MV, Jørgensen K, Albrecht M, Haugen MH, Egeland EV, Lucarelli P, Sauter T, Engebraaten O, Mælandsmo GM, Prasmickaite L Targetable nodes in fibroblast-supported melanoma cells that show resistance to BRAF inhibitors. AACR Annual Meeting 2017-American Association for Cancer Research, 77(13): 4329.

Talks:

Alexopoulos L Pathway analysis tools for drug discovery: Applications in liver cancer, cartilage degeneration, and melanoma. Institute for cell biology and immunology, University of Stuttgart, 26 June 2017.

Alexopoulos L Applied Interdisciplinary Research for Academia & Industry. Whitaker Enrichment Seminar, Athens, Greece, 12 August 2017.

Alexopoulos L Pathway-based approaches for early drug and biomarker discovery. Research and Industrial applications in osteoarthritis, liver cancer, non-alcoholic fat liver disease, multiple sclerosis, melanoma, chronic kidney disease, and liver toxicity. Workshop in Network Biology/Integromics Bioinformatics – Applications Towards Medicine, Bergen, 23-25 August 2017.

Bosisio FM, Wouters J, Stas M, Bolognesi, M, Scalia, C & van den Oord J In situ evaluation of markers of activation and inhibition of Tumor Infiltrating Lymphocytes (TILs) after microdissection: remarks to the current morphologic classification of the “TILs patterns”. Irish association for Cancer Research Annual Meeting, 22-25 February 2017.

Bosisio FM, Wouters J, Stas M, Cattoretti G & van den Oord J In situ evaluation of markers of activation and inhibition of Tumor Infiltrating Lymphocytes (TILs) after microdissection: remarks to the current morphologic classification of the “TILs patterns”. European Association of Dermato-Oncology, 03-06 May 2017.

Bosisio FM, Rahman A, Blanco A, Peralbo E, Elliott L, Pliaka V, Minia A, Antoranz A, Ryan E, Alexopoulos L, van den Oord J & Gallagher W Melanin exposure favours M2-like polarization in macrophages. EORCT Fall Meeting, 05-06 October 2017.

Cecconi F From lysosome to autophagy: a “synergistic” success story. Center for Autophagy, Recycling and Disease (CARD) seminar meeting “Celebration of Nobel Prize of Autophagy” Copenhagen, Denmark, 18 January 2017.

Cecconi F Autophagy and ubiquitylation, friends or foes?  ZOMES IX CONFERENCE 2017, Rome, Italy, 14-17 February 2017.

Cecconi F Presentation of the research group. Scientific Advisory Board evaluation 24 February 2017.

Cecconi F AMBRA1 through evolution at the crossroad among autophagy, cell proliferation and cell death. 12th International Meeting on Yeast Apoptosis, Bari, Italy 14-18 May 2017.

Cecconi F Autophagy regulation of cell division. The 8th International Symposium on Autophagy, Nara, Japan, 29 May – 01 June 2017.

Cecconi F Autophagy and cell division: of centrosomes, mitosis and cancer. The Annual ICDS Conference The Batsheva de Rothschild Seminar on Cell Death in Development and Disease, The David Lopatie Conference Centre, Weizmann Institute of Science, Rehovot, Israel, 18-20 June 2017.

Cecconi F Autophagy in health and disease. XXVI AINI Congress 16th ESNI Course, June 26-28, 2017, San Servolo Island, Venice, Italy, 26-28 June 2017.

Cecconi F Autophagy and cell division: of  centrosomes, mitosis and cancer. PhD Course in Scienze Biomediche, Padova, Italy, 04 July 2017.

Cecconi F Autophagy and ubiquitylation, friends or foes? 42nd Congress of The Federation of the European Biochemical Societies (FEBS), Jerusalem, Israel, 10-14 September 2017.

Cecconi F Autophagy and cell division: of centrosomes, mitosis and cancer. EMBO conference Autophagy: From molecular principles to human diseases” Cavtat, Croatia, 25-29 September 2017.

Cecconi F

1) Preview and Perspective: Autophagy, in stress response and cell death regulation

2) Autophagy and cell division: of centrosomes, mitosis and cancer

2nd IFOM Symposium – Advanced Lecture Course Ubiquitin-assisted autophagy from mechanisms to pathology, IFOM, Milan – Italy, 11-13 October 2017.

Cecconi F Presentation of the research group. Meeting with new DCS director 10 October 2017.

Chiquero-Leon E, Rauch N, Romano D, Rauch J, Kolch W Regulation of the human Hippo/MST2 pathway in drug-mediated resistant melanoma. UCD Conway Festival of Research & Innovation, UCD, Dublin – 13/09/2017. 

Chiquero-Leon E Regulation of the human Hippo/MST2 pathway in Raf inhibitor mediated resistant melanoma. Massachusetts General Hospital 24 July 2017.

De Landtsheer S, Trairatphisan P, Lucarelli P & Sauter T. FALCON: A Fast Algorithm for the Contextualisation of Logical Network Models. BC2 Basel Computational Biology Conference 2017, 12 September 2017.

De Landtsheer S, Trairatphisan P, Lucarelli P & Sauter T. FALCON: A Fast Algorithm for the Contextualisation of Logical Network Models. SBHD17 Systems Biology of Human Diseases, Heidelberg, 04-06 October 2016.

De Zio D Presentation of the in vivo projects of the Unit. Scientific Advisory Board evaluation 24 February 2017.

Fitzgibbon C, Chiquero-Leon E, Liu Z, Rauch N, Panada E, von Kriegsheim A, Kolch W & Rauch J Tackling acquired resistance mechanisms in malignant melanoma. European Alliance for Personalised Medicine (EAPM), Waterfront Convention Centre, Belfast, Northern Ireland – 28/11/2017.

Fitzgibbon C, Chiquero-Leon E, Liu Z, Rauch N, Panada E, von Kriegsheim A, Kolch W & Rauch J Tackling acquired resistance mechanisms in malignant melanoma. Irish Association for Cancer Research Annual Meeting, Kilkenny, Ireland, 23 February 2017.

Frangež Ž The role of autophagy and its related genes in melanoma progression. 15th International Summer School, University of Bern, 23 July 2017.

Guttà C A systems-level analysis of autophagy as a potential novel approach towards melanoma prognosis. Stuttgart Research Centre Systems Biology Workshop, Stuttgart, Germany (flash talk), 14 December 2016.

Guttà C Development of a prototype predictive assay for melanoma based on apoptotic biomarkers. 11th PhD Workshop on Molecular Mechanisms and Therapeutic Approaches in Cancer, Freudenstadt, Germany, 20-22 September 2017.

Khorsand F, Rukhlenko O, Fitzgibbon C, Chiquero-Leon E, Liu Z, Rauch N, Panada E, Lee S, Rozanc J, Alexopoulos L, Gómez-Coca S, Rosta E, Kholodenko B, Kolch W & Rauch J Tackling acquired resistance mechanisms in malignant melanoma. UCD Computational and Molecular Biology PhD Symposium 2017, UCD Conway Institute Dublin, Ireland – 01/12/2017.

Kulms D Caspase-8, the bad guy in cancer?! 10th Tuscany Retreat on Cancer Research and Apoptosis, Sarteano-Siena, Italy, August 2017. 

Kulms D Caspase-8, the bad guy in cancer?! Department of Cellular and Molecular Medicine University of Leuven, October 2017. 

Müller I, Strozyk E, Hausser A, Beissert S, Walczak H, Daugaard M, Simon HU & Kulms D Caspase-8 promotes uncontrolled progression of cancer cells. EMBO Workshop: Cell death, inflammation and cancer, Obergurgel, Austria, January 2017.

Müller I, Strozyk E, Schindler S, Del Mistro G, Beissert S, Zarni Oo H, Sauter T, Lucarelli P, Raeth S, Hausser A, Al Nakouzi N, Zhai B, Fazli L, Gleave M, Liu H, Simon HU, Walczak H, Green DR, Daugaard M & Kulms D Cancer cells employ nuclear caspase-8 to overcome the p53-dependent G2/M checkpoint. 25th Conference of the European Cell Death Organization, Leuven, Belgium, September 2017.

Rehm M Cell Death Signaling – mechanistic insight and translational applications. University Clinics Regensburg Seminar Series, Germany, February 2017.

Rehm M Cell death control – from mechanisms to applications. Werner Siemens Imaging Center Seminar Series, University of Tübingen, Germany, June 2017.

Rufo N Systems Biology of Immunogenic Cell Death (ICD) in Melanoma. KU Leuven & UZ Leuven Research Day on Tumor Immunology & Immunotherapy, 18 May 2017.

Simon HU Autophagy and cancer. 15th International Summer School, University of Bern, 23 July 2017.

Vetma V Development and validation of tools that can predict cell death induced by 2nd generation TRAIL receptor ligand. 11th PhD Workshop on Molecular Mechanisms and Therapeutic Approaches in Cancer, Freudenstadt, Germany, 20-22 September 2017.

2016

POSTERS:

Albrecht M, Sciumè G, Lucarelli P & Sauter T Thermodynamically constrained averaging theory for cancer growth modelling. University Luxemburg, 24-25 November 2016.

Bodemeyer V, Cianfanelli V, De Zio D & Cecconi F Understanding the role of Ambra 1-based signaling in melanoma development. 5th Annual Conference of the Nordic Autophagy Network, Keflavik, Iceland, August 31 – September 2 2016.

Bosisio FM, Wouters J, Volders N, Stas M & van den Oord JJ A functional in situ approach to TILs in melanoma: a critique on the current morphological classification. USCAP Meeting, Seattle, USA, 12-18 March 2016.

Bosisio FM, Dehur M-S, Wouters J, Volders N, Stas M, van Baren N & van den Oord J In situ immunophenotyping of tumour infiltrating lymphocytes and MHC molecules expression in melanoma metastasis: a preliminary study. USACP Meeting, Seattle, USA, 12-18 March 2016. – BEST POSTER ORAL PRESENTATION PRIZE.

Bosisio FM, Kalender Atak Z, Wouters J & van den Oord JJ Expressomics investigation of MHC II positive areas in melanoma. International Congress of the IAP and 28th Congress of the ESP, Cologne, Germany, 25-29 September 2016. – BEST POSTER ORAL PRESENTATION PRIZE.

Bosisio FM, Wouters J, Stas M, Bolognesi, M, Scalia, C & van den Oord J In situ evaluation of markers of activation and inhibition of Tumor Infiltrating Lymphocytes (TILs) after microdissection: remarks to the current morphologic classification of the “TILs patterns”. Irish Melanoma Meeting, 02 December 2016 – BEST POSTER PRESENTATION PRIZE.

Chiquero-Leon E, Fitzgibbon C, Rauch N, Romano D, Rauch J & Kolch W Regulation of the huma Hippo/MST2 pathway in Raf inhibitor mediated resistant melanoma. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Chiquero-Leon E, Rauch N, Romano D, Rauch J & Kolch W Regulation of the human Hippo/MST2 pathway in Raf inhibitor mediated resistant melanoma. SBI Scientific Advisory Board Meeting, 09 December 2016.

Del Mistro G & Kulms D Impact of sublethal drug doses on melanoma cell behavior and tumor relapse. 10th CRTD Summer Conference on Regenerative Medicine, Dresden, Germany, 3 June 2016.

Del Mistro G, Beissert S & Kulms D Mechanistic insight into the consequences of sublethal drug doses and the tumor microenvironment on the therapeutic responses and enwanted metastatic outgrowth of malignant melanoma. 46th Annual Meeting of the European Society for Dermatology Research, Munich, Germany, 7-10 September 2016.

Del Mistro G, Mueller I, Beissert S & Kulms D Mechanistic insight into the consequences of sublethal drug doses and the tumor microenvironment on therapeutic responses and unwanted metastatic outgrowth of malignant melanoma. 24th Conference of the European Cell Death Organization, “Cell Death in Health and Disease, Barcelona, Spain, 28-30 September 2016.

Frangez Z, Liu H, He Z & Simon HU Epigenetic regulation of autophagy and its role for melanoma progression and metastasis. 9th Swiss Apoptosis Meeting, Bern, Switzerland, 8-9 September 2016.

Guttà C, Frangež Ž, Hirschenhahn E, Liu H, Simon HU & Rehm M A systems-level analysis of autophagy as a potential novel approach towards melanoma prognosis. Stuttgart Research Centre Systems Biology Workshop, Stuttgart, Germany, 14 December 2016.

Hirschenhahn E, Gutta C, Liu H, Simon HU & Rehm M A systems-level analysis of autophagy as a potential novel approach towards melanoma prognosis. 9th Swiss Apoptosis Meeting, Bern, Switzerland, 8-9 September 2016.

Lucarelli P, Del Mistro G, De Landtsheer S, Trairatphisan P, Kulms D & Sauter T Analysis of the TRAIL and cisplatin induced apoptosis and MAPK-PI3K/AKT signal transduction pathways in melanoma with a probabilistic Boolean network approach. 6th Conference on Systems Biology of Mammalian Cells, Munich, Germany, 6-8 April 2016.

Lucarelli P, De Landtsheer S, Trairatphisan P & Sauter T FALCON: A Fast Algorithm for the Contextualisation of Logical Network Models. e:Med 2016, Kiel, Germany, 4-6 October 2016.

Müller I, Del Mistro G, Lucarelli P, Sauter T & Kulms D Mechanistic insight into the consequences of sublethal drug doses on therapeutic responses and unwanted metastatic outgrowth of malignant melanoma. E:Med Meeting on Systems Medicine, October 2016.

Praetorius C, Kulms D, Westphal D, Morrison (Rehm) M & Meier F Compounds triggering ER stress-induced cell death in NRASmut melanoma – Can response be predicted? E:Med Meeting on Systems Medicine, October 2016.

Rufo N, Sauter T, Marine JC, Garg AD & Agostinis P Systems biology of immunogenic cell death in melanoma. Applied Bioinformatics in Life Sciences, Leuven, Belgium, 17-18 March 2016.

Rufo N, Sauter T, Marine JC, Garg AD & Agostinis P Systems biology of immunogenic cell death in melanoma. EACR 24, Manchester, UK, 9-12 July 2016.

Rufo N, Garg AD, Sauter T, Marine JC, Agostinis P Systems biology of immunogenic cell death in melanoma. LKI Symposium on Tumor Immunology & Immunotherapy, Leuven, Belgium, 12-14 September 2016.

Rufo N, Garg AD, Sauter T, Marine JC & Agostinis P Systems Biology of Immunogenic Cell Death (ICD) in Melanoma. Cell-VIB symposium “Hallmarks of Cancer” 11-13 December 2016.

Vetma V, Charles E, Hutt M, Hellwig C, Kontermann R, Pfizenmeier K & Rehm M Examining the efficacy of dacarbazine and birinapant in melanoma cell lines. EWCD – 10th European Workshop in Cell Death, Fiuggi, Italy, 3-8 April 2016.

Vetma V, Kulms D, Kontermann R & Rehm M An approach towards predicting melanoma cell death induced by 2nd generation TRAIL receptor agonist IZI1551 in single and combination treatment with IAP antagonist TL32711/Birinapant. E:Med Meeting on Systems Medicine, October 2016.

 

Published abstracts:

Albrecht M, Sciume G, Lucarelli P & Sauter T Thermodynamically constrained averaging theory for cancer growth modellig. 6th IFAC Conference on Foundations of Systems Biology in Engineering, October 9th-12th 2016, Magdeburg, Germany.

Bosisio FM, Dehur MS, Wouters J, Volders N, Stas M, van Baren N & van den Oord JJ In situ evaluation of the correlation between the pattern of Tumor Infiltrating Lymphocytes, INF-gamma levels and MHC molecules expression in Melanoma Metastasis: remarks to the current morphologic classification. Virchows Archiv 469 (Suppl 1):S1–S346.

Bosisio FM, Kalender Atak Z, Wouters J & van den Oord JJ Expressomics investigation of MHC II positive areas in melanoma. Virchows Archiv 469 (Suppl 1):S1–S346.

Rufo N, Sauter N, Marine JC, Garg AD & Agostinis P Systems Biology of immunogenic cell death in melanoma. EACR24, July 9th-12th 2-16, Manchester, UK.

Vetma V, Charles E, Hellwig C & Rehm M Examining the efficacy of Dacarbazine and Birinapant combination treatment in melanoma cell lines. 5th Irish Melanoma Forum, December 15th 2015, Dublin, Ireland.

Talks:

Agostinis P Shedding new light on PERK’s function in calcium signaling and immunogenic cell death. ER stress in health and disease, Galway, Ireland, 19 May 2016.

Agostinis P Harnessing ER stress for immunotherapy against cancer: from translational medicine to molecular mediatorsNobel Conference No 63 – The cell cycle and cell death in disease, Nobel Forum Karolinska, Stockholm, Sweden, 08-11 June 2016.

Agostinis P Autophagy as modulator of tumor-stroma interactions. 3rd Annual Meeting of the International Society of Cancer Metabolism (ISCaM), Brussels, Belgium, 26-30 October 2016.

Albrecht M Multi-scale modeling environment for melanoma growth arrest and recurrence. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Albrecht M Network medicine meets mechanical tumour models: a new way to personalized medicine. Residential Workshop on Computational Sciences for Medical Simulations: Surgical Training and Guidance, Luxembourg, 12-14 December 2016.

Alexopoulos L Systems pharmacology for melanoma biomarker discovery, Invited seminar at University of Stuttgart, Germany, 29 June 2016.

Bodemeyer V Understanding the role of Ambra1-based signaling in melanoma development. Summer School “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Bosisio F In situ analysis of the micro-environmental immune-signature of primary melanoma and its validation as a prognostic marker for melanoma regression. Summer School “Anglo-German Research Training Initiative!, London, UK, 18-22 July 2016.

Bosisio FM, Wouters J, Stas M, Cattoretti G & van den Oord J In situ evaluation of markers of activation and inhibition of Tumor Infiltrating Lymphocytes (TILs) after microdissection: remarks to the current morphologic classification of the “TILs patterns”. EORTC Fall Melanoma Meeting, 27-28 October 2016.

Bosisio FM, Wouters J, Stas M, Cattoretti G & van den Oord J In situ evaluation of markers of activation and inhibition of Tumor Infiltrating Lymphocytes (TILs) after microdissection: remarks to the current morphologic classification of the “TILs patterns”. Society for Melanoma Research Annual Meeting, 04-09 November 2016.

Bosisio FM In situ analysis of the melanoma micro-environment. Annual meeting of the Italian Society of Pathology (SIAPEC-IAP), 23 November 2016.

Bosisio FM, Wouters J, Stas M, Bolognesi, M, Scalia, C & van den Oord J In situ evaluation of markers of activation and inhibition of Tumor Infiltrating Lymphocytes (TILs) after microdissection: remarks to the current morphologic classification of the “TILs patterns”. Irish Melanoma Meeting, 02 December 2016.

Cecconi F Autophagy upstream regulation and its relevance in cancer ontogenesis. European Association for Cancer Research (EACR) Conference – A matter of life and death, Amsterdam, Netherlands, 28 January 2016.

Cecconi F Presentation of the Unit CSS with related projects. Center for Autophagy, Recycling and Disease (CARD) seminar meeting “kick-off meeting”, Copenhagen, Denmark, 6 November 2016.

Chiquero-Leon E Understanding how the human Hippo/MST2 pathway mediates in drug-resistant melanoma. Bioinformatics seminars Conway Institute, Dublin, Ireland, 30 May 2016.

Chiquero-Leon E Regulation of the human Hippo/MST2 pathway in Raf inhibitor mediated resistant melanoma. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

De Landtsheer S A pipeline for the identification of network structures for the modeling of melanoma-specific signaling pathways. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Del Mistro G & Kulms D Impact of sublethal drug doses on melanoma cell behavior and tumor relapse. EWCD – 10th European Workshop in Cell Death, Fiuggi, Italy, 3-8 April 2016.

Del Mistro G Mechanistic insight into the consequences of sublethal IZI1551 doses to prevent unwanted proliferation and migration of melanoma metastasis. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Frangez Z, Deciphering the function of dynamic DNA epigenetic signatures as regulatory networks for melanoma progression and metastasis. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Gutta C & Rehm M Constructing and validating an autophagy-based modeling environment as a systems-biological prognostic marker for primary melanoma. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Kulms D 3D präklinische Testsysteme für die Melanomtherapie. 26th Annual Workshop on Skin Cancer (ADO), Dresden, Germany, 21 September 2016.

Lucarelli, P, De Landtsheer S, Trairatphisan P & Sauter T FALCON: A Fast Algorthm for the Contextualisation of Logical Network Models. e: Med 2016, Kiel, Germany, 4-6 October 2016.

Mueller I, Strozyk E, Hausser A, Beissert S, Walczak H & Kulms D Caspase-8 promotes uncontrolled progression of cancer cells. Gordon Conference: “New Concepts in Cell Death Research: From Basic Mechanisms to Clinical Opportunities”, Girona, Spain, 3-8 July 2016.

Mueller I, Strozyk E, Hausser A, Beissert S, Walczak H, Daugaard M, Simon HU & Kulms D Caspase-8 promotes uncontrolled progression of cancer cells. European Cell Death Organisation Annual Conference, Barcelona, Spain, 28-30 September 2016.

Palonen K Identifying and validating a panel of master transcriptional regulators in advanced melanoma using a systems transcriptomics and histology approach. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Perez-Silva L & Kulms D Targeted melanoma therapeutics contribute to tumor relapse!? EWCD – 10th European Workshop in Cell Death, Fiuggi, Italy, 3-8 April 2016.

Perez-Silva L Predicting susceptibility to mutation specific targeted drugs using quantitative modeling approaches in malignant melanoma. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Podder B Understanding the umpact of necroptosis inhibitors on cell death resistance of malignant melanoma. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Rauch J, Chiquero-Leon E, Kolch W Overcoming Drug Resistance in Metastatic Malignant Melanoma. Irish Melanoma Forum, 02 December 2016.

Rehm M Achievements and challenges in translational systems biology and systems medicine. CASyM/SysMedIBD workshop: European Systems Medicine – Are we there yet?, Brussels, Belgium, 16 February 2016.

Rehm M Systems medicine strategies in colorectal cancer. ZPM Annual Conference, Hegne, Germany, April 2016.

Rehm M The apoptosis execution network and chemotherapy responsiveness – avenues for systems medicine applications. 9th Swiss Apoptosis Meeting, Bern, Switzerland, 8-9 September 2016.

Rehm M A stepwise integrated approach to personalized risk predictions in stage III colorectal cancer building on tumor apoptosis competency. European Cell Death Organisation Annual Conference, Barcelona, Spain, 28-30 September 2016.

Rehm M MEL-PLEX – European Translational Systems Biology Training. European Association for Systems Medicine (EASyM), Berlin, Germany, 26-28 October 2016.

Rehm M The apoptosis execution network and chemotherapy responsiveness – avenues for systems medicine applications. European Association for Systems Medicine (EASyM), Berlin, Germany, 26-28 October 2016.

Rehm M Cell Death Signaling – from experimentation to innovative applications. German Excellence Cluster “Simulation Technology” Colloquium Series, Stuttgart, Germany, November 2016.

Rehm M Choice cuts of death. Biochemistry Seminar series University of Tubingen, Germany, December 2016.

Rozanc J Identifying phosphoprotein and cytokine patterns indicative of responsiveness to targeted therapy for melanoma. Invited seminar at National Technical University of Athens, Greece, 20 May 2016.

Rozanc J Identification of predictive phosphor-signatures for targeted therapy in melanoma. Summer school “Anglo-German Research Training Initiative” London, UK, 18-22 July 2016.

Rufo N Systems analysis of immunogenic cell death (ICD) in melanoma to evaluate ICD signatures as prognostic or predictive markers of treatment responsiveness. Summer School “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Simon HU Autophagy and cancer. 15th International Summer School, University of Bern, Switzerland, 7-9 August 2016.

Simon HU Autophagy in health and disease. Swiss Apoptosis Meeting, Bern, Switzerland, 7-9 August 2016.

Tsur N Predicting responses to immunotherapy in metastatic by melanoma by personalized mathematical models. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Vetma V Examining the efficacy of Dacarbazine and Birinapant combination treatment in melanoma cell lines.Thesis in 3″, RCSI Research Day, Dublin Ireland, 16 February 2016.

 Vetma V, Kulms D & Rehm M Development and validation of tools that predict cell death induced by the 2nd generation TRAIL receptor ligand. Summer School “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.


 

 

2015

POSTERS:

Albrecht M & Sauter T Simulation tool mimics the underlying processes in a 3D organotypic skin-melanoma spheroid model and allows for fast in silico pre-testing of agents. 12th International Congress of the Society for Melanoma Research, San Francisco, USA, 18-21 November 2015.

Bodemeyer V, Cianfanelli V, DeZio D & Cecconi F Understanding the role of AMBRA-1-based signalling in melanoma development. MoMeD Summer School, Copenhagen, Denmark, 11-12 June 2015.

Bosisio FM, van Baren N, Wouters J, Stas M & van den Oord JJ  Significance of plasma cells in melanoma. Oncoforum, Leuven, Belgium, 05 June 2015.

Bosisio FM, Mercier M, Wilmott J, van Baren N, Wouters J, Scolyer R, Stas M & van den Oord JJ Significance of plasma cells in melanoma. 12th International Congress of the Society for Melanoma Research, San Francisco, USA, 18-21 November 2015.

Chiquero-Leon E, Rauch N, Romano D, Kolch W & Rauch J Regulation of the human Hippo/MST2 pathway in Raf inhibitor mediated resistant melanoma. UCD Conway Festival of Research & Innovation, Dublin, Ireland, 09-10 September 2015.

De Landtsheer S, Trairatphisan P & Sauter T Probabilistic Boolean networks as a tool to study melanoma signalling pathways. 12th International Congress of the Society for Melanoma Research, San Francisco, USA, 18-21 November 2015.

Lucarelli P, De Landtsheer S, Trairatphisan P & Sauter T Analysis of the TRAIL-induced apoptosis and ERK-MAPK signal transduction pathways in cancer cell lines by a probabilistic Boolean network approach. e:Med 2015, Heidelberg, Germany, 26-28 October 2015.

Vetma V & Rehm M Examining the effectiveness of Dacarbazine and Birinapant combination treatment in melanoma cell lines. 1st Bilateral Research Interaction Symposium – Cell Biology of Human Disease: From Molecular Mechanisms to Applications, Stuttgart, Germany, 14-16 October 2015.

 Published abstracts:

Albrecht M, Kulms D & Sauter T Simulation tool mimics the underlying processes I a 3D organotypic skin-melanoma spheroid model and allows for fast on silico pre-testing of agents. Pigment Cell & Melanoma Res doi: 10.1111/pcmr.12419. Link here.

Niessner H, Wanke I, Sinnberg T, Westphal D, Praetorius C, Schittek B, Beisert S, Kulms D, Garbe C, Meier F Effects of BRAFV600 inhibitors on endoplasmatic reticulum stress and sensitivity of NRas-mutated melanoma cells to different MEK inhibitors. Pigment Cell & Melanoma Res doi: 10.1111/pcmr.12419.

Westphal D, Niessner H, Schmitz J, Schmid A, Sinnberg T, Tabatabai G, Weide B, Garbe C, De Fend LQ, Mai M, Beissert S, Kulms D, Schackert G, Muders M, Meinhardt M, Baretton G, Pilcher B, Meier F The IGF-1R-PI3K-AKT pathway – a therapeutic target in melanoma brain metastases? Pigment Cell & Melanoma Res doi: 10.1111/pcmr.12419.

TALKS:

Agostinis P Unfolding new functions of PERK beyond the UPR. EMBO Workshop on “Mitochondria, Apoptosis & Cancer” (MAC’15), Frankfurt, Germany, 10-12 September 2015.

Agostinis P The PERKs of immunogenic cancer cell death. ICDS Conference “Implementations of knowledge of cell death”, Prague, Czech Republic, 28-30 May 2015

Agostinis P ER Stress and Calreticulin in immunogenic cell death. Invited seminar at the Duve Institute, Brussels, Belgium, 22 May 2015.

Agostinis P Unfolding the complexities of ER chaperones in health and disease. 11th International Calreticulin Workshop, “Unfolding the complexities of ER Chaperones in health and disease, New York University (NYU) School of Medicine, New York , USA, 08-15 May 2015.

Aparicio I Innovation and perspectives for doctoral training. 1st Bilateral Research Interaction Symposium. Cell Biology of Human Disease: From Molecular Mechanisms to Applications, Stuttgart, Germany, 14-16 October 2015.

Bosisio FM, van Baren N, Wouters J, Stas M & van den Oord J Significance of plasma cells in melanoma. Belgiam Week of Pathology, Ghent, Belgium, 21-24 October 2015.

Bosisio FM, van Baren N, Wouters J, Stas M & van den Oord J Significance of plasma cells in melanoma. European Congress of Pathology, Belgrade, Serbia, 05-09 September 2015.

Cecconi F Autophagy upstream regulations: of pulse, coordination and efficiency. 4th Annual Nordic Autophagy Meeting, Helsinki, Finland, 05-07 June 2015.

Gallagher W Translational melanoma research in Ireland: an update. Irish Melanoma Forum, Dublin, Ireland, 4 December 2015.

Hirschenhahn E Data-driven systems modelling to prognosticate cancer recurrence and progression. 1st Bilateral Research Interaction Symposium – Cell Biology of Human Disease: From Molecular Mechanisms to Applications, Stuttgart, Germany, 14-16 October 2015.

Kulms D The p53 and NFkB cross-talk: Friends or Foes? 23rd Conference of the European Cell Death Organization,‘Death pathways and beyond’, Geneva, Switzerland, 07-10 October 2015.

Kulms D The p53 and NFkB cross-talk: Friends or Foes? 9th Tuscany Retreat on Cancer Research and Apoptosis, “Genetic profiling, resistance mechanism and novel treatment concepts in cancer”, Sarteano-Siena, Italy, 01-08 August 2015.

Kulms D Caspase-8: Death or survival?!. Cell Death and Disease Workshop, Villa Vigoni, Italy, 24-27 June 2015.

Kulms D Three dimensional melanoma treatment using the death ligand TRAIL15th International TNF conference in Ghent, Belgium: 20-23 May, 2015

Kulms D Identification of therapeutic targets in skin cancer using experimental and mathematical modeling approaches. Invited Seminar, University of Luxembourg, 17 February 2015.

Rauch N, McCann B, Chiquero-Leon E, Santra T, Baljuls A, Pilkington R, Kennedy S, von Kriegsheim A, Rauch J & Kolch W Partners in crime – Signalling through Raf heterodimers. 4th International Conference on Analytical Proteomics, Caparica, Portugal, 07-09 September 2015.

Sauter T & Aparicio I Overview of MEL-PLEX ETN – Life sciences parallel session. Future of the Doctorate (EU Presidency Conference) Riga, Latvia, 28-29 May 2015.

Rehm M From cancer cell biology to systems medicine applications. Invited Seminar, German-Austrian-Swiss Research Group FOR-2036, Obergurgl, Austria, April 2015.

Rehm M From cancer systems biology to systems medicine. Invited Seminar, Guangzhou Medical University, Guangzhou City, China, March 2015.

Rehm M Cell death signalling – mechanistic insight and translational applications. Invited Seminar, Queens University, Belfast, UK, January 2015.

Westphal D, Niessner H, Schmitz J, Schmid A, Sinnberg T, Tabatai G, Weide B, Garbe C, De Fend LQ, Mai M, Beissert S, Kulms D, Schackert G, Muders M, Meinhardt M, Baretton G, Pilcher B & Meier F The IGF-1R-PI3K-AKT pathway – a therapeutic target in melanoma brain metastases? 12th International Meeting of the Society for Melanoma Research, San Francisco, USA, 18-21 November 2015

2014

TALKS:

Rehm M From cancer cell biology to systems medicine applications. Invited Seminar, Charite University Clinics, Berlin, Germany, December 2014.

Print Friendly, PDF & Email

Leave a Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.