Conference Contributions

2016

POSTERS:

Bodemeyer V, Cianfanelli V, De Zio D & Cecconi F Understanding the role of Ambra 1-based signaling in melanoma development. 5th Annual Conference of the Nordic Autophagy Network, Keflavik, Iceland, August 31 – September 2 2016.

Bosisio FM, Wouters J, Volders N, Stas M & van den Oord JJ A functional in situ approach to TILs in melanoma: a critique on the current morphological classification. USCAP Meeting, Seattle, USA, 12-18 March 2016.

Bosisio FM, Dehur M-S, Wouters J, Volders N, Stas M, van Baren N & van den Oord J In situ immunophenotyping of tumour infiltrating lymphocytes and MHC molecules expression in melanoma metastasis: a preliminary study. USACP Meeting, Seattle, USA, 12-18 March 2016. – BEST POSTER ORAL PRESENTATION PRIZE.

Bosisio FM, Kalender Atak Z, Wouters J & van den Oord JJ Expressomics investigation of MHC II positive areas in melanoma. International Congress of the IAP and 28th Congress of the ESP, Cologne, Germany, 25-29 September 2016. – BEST POSTER ORAL PRESENTATION PRIZE.

Chiquero-Leon E, Fitzgibbon C, Rauch N, Romano D, Rauch J & Kolch W Regulation of the huma Hippo/MST2 pathway in Raf inhibitor mediated resistant melanoma. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Del Mistro G & Kulms D Impact of sublethal drug doses on melanoma cell behavior and tumor relapse. 10th CRTD Summer Conference on Regenerative Medicine, Dresden, Germany, 3 June 2016.

Del Mistro G, Beissert S & Kulms D Mechanistic insight into the consequences of sublethal drug doses and the tumor microenvironment on the therapeutic responses and enwanted metastatic outgrowth of malignant melanoma. 46th Annual Meeting of the European Society for Dermatology Research, Munich, Germany, 7-10 September 2016.

Del Mistro G, Mueller I, Beissert S & Kulms D Mechanistic insight into the consequences of sublethal drug doses and the tumor microenvironment on therapeutic responses and unwanted metastatic outgrowth of malignant melanoma. 24th Conference of the European Cell Death Organization, “Cell Death in Health and Disease, Barcelona, Spain, 28-30 September 2016.

Frangez Z, Liu H, He Z & Simon HU Epigenetic regulation of autophagy and its role for melanoma progression and metastasis. 9th Swiss Apoptosis Meeting, Bern, Switzerland, 8-9 September 2016.

Hirschenhahn E, Gutta C, Liu H, Simon HU & Rehm M A systems-level analysis of autophagy as a potential novel approach towards melanoma prognosis. 9th Swiss Apoptosis Meeting, Bern, Switzerland, 8-9 September 2016.

Lucarelli P, Del Mistro G, De Landtsheer S, Trairatphisan P, Kulms D & Sauter T Analysis of the TRAIL and cisplatin induced apoptosis and MAPK-PI3K/AKT signal transduction pathways in melanoma with a probabilistic Boolean network approach. 6th Conference on Systems Biology of Mammalian Cells, Munich, Germany, 6-8 April 2016.

Lucarelli P, De Landtsheer S, Trairatphisan P & Sauter T FALCON: A Fast Algorithm for the Contextualisation of Logical Network Models. e:Med 2016, Kiel, Germany, 4-6 October 2016.

Rufo N, Sauter T, Marine JC, Garg AD & Agostinis P Systems biology of immunogenic cell death in melanoma. Applied Bioinformatics in Life Sciences, Leuven, Belgium, 17-18 March 2016.

Rufo N, Sauter T, Marine JC, Garg AD & Agostinis P Systems biology of immunogenic cell death in melanoma. EACR 24, Manchester, UK, 9-12 July 2016.

Rufo N, Garg AD, Sauter T, Marine JC, Agostinis P Systems biology of immunogenic cell death in melanoma. LKI Symposium on Tumor Immunology & Immunotherapy, Leuven, Belgium, 12-14 September 2016.

Vetma V, Charles E, Hutt M, Hellwig C, Kontermann R, Pfizenmeier K & Rehm M Examining the efficacy of dacarbazine and birinapant in melanoma cell lines. EWCD – 10th European Workshop in Cell Death, Fiuggi, Italy, 3-8 April 2016.

Published abstracts:

Albrecht M, Sciume G, Lucarelli P & Sauter T Thermodynamically constrained averaging theory for cancer growth modellig. 6th IFAC Conference on Foundations of Systems Biology in Engineering, October 9th-12th 2016, Magdeburg, Germany.

Bosisio FM, Dehur MS, Wouters J, Volders N, Stas M, van Baren N & van den Oord JJ In situ evaluation of the correlation between the pattern of Tumor Infiltrating Lymphocytes, INF-gamma levels and MHC molecules expression in Melanoma Metastasis: remarks to the current morphologic classification. Virchows Archiv 469 (Suppl 1):S1–S346.

Bosisio FM, Kalender Atak Z, Wouters J & van den Oord JJ Expressomics investigation of MHC II positive areas in melanoma. Virchows Archiv 469 (Suppl 1):S1–S346.

Rufo N, Sauter N, Marine JC, Garg AD & Agostinis P Systems Biology of immunogenic cell death in melanoma. EACR24, July 9th-12th 2-16, Manchester, UK.

Vetma V, Charles E, Hellwig C & Rehm M Examining the efficacy of Dacarbazine and Birinapant combination treatment in melanoma cell lines. 5th Irish Melanoma Forum, December 15th 2015, Dublin, Ireland.

Talks:

Agostinis P Shedding new light on PERK’s function in calcium signaling and immunogenic cell death. ER stress in health and disease, Galway, Ireland, 19 May 2016.

Agostinis P Harnessing ER stress for immunotherapy against cancer: from translational medicine to molecular mediatorsNobel Conference No 63 – The cell cycle and cell death in disease, Nobel Forum Karolinska, Stockholm, Sweden, 08-11 June 2016.

Agostinis P Autophagy as modulator of tumor-stroma interactions. 3rd Annual Meeting of the International Society of Cancer Metabolism (ISCaM), Brussels, Belgium, 26-30 October 2016.

Albrecht M Multi-scale modeling environment for melanoma growth arrest and recurrence. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Albrecht M Network medicine meets mechanical tumour models: a new way to personalized medicine. Residential Workshop on Computational Sciences for Medical Simulations: Surgical Training and Guidance, Luxembourg, 12-14 December 2016.

Alexopoulos L Systems pharmacology for melanoma biomarker discovery, Invited seminar at University of Stuttgart, Germany, 29 June 2016.

Bodemeyer V Understanding the role of Ambra1-based signaling in melanoma development. Summer School “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Bosisio F In situ analysis of the micro-environmental immune-signature of primary melanoma and its validation as a prognostic marker for melanoma regression. Summer School “Anglo-German Research Training Initiative!, London, UK, 18-22 July 2016.

Cecconi F Autophagy upstream regulation and its relevance in cancer ontogenesis. European Association for Cancer Research (EACR) Conference – A matter of life and death, Amsterdam, Netherlands, 28 January 2016.

Cecconi F Presentation of the Unit CSS with related projects. Center for Autophagy, Recycling and Disease (CARD) seminar meeting “kick-off meeting”, Copenhagen, Denmark, 6 November 2016.

Chiquero-Leon E Understanding how the human Hippo/MST2 pathway mediates in drug-resistant melanoma. Bioinformatics seminars Conway Institute, Dublin, Ireland, 30 May 2016.

Chiquero-Leon E Regulation of the human Hippo/MST2 pathway in Raf inhibitor mediated resistant melanoma. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

De Landtsheer S A pipeline for the identification of network structures for the modeling of melanoma-specific signaling pathways. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Del Mistro G & Kulms D Impact of sublethal drug doses on melanoma cell behavior and tumor relapse. EWCD – 10th European Workshop in Cell Death, Fiuggi, Italy, 3-8 April 2016.

Del Mistro G Mechanistic insight into the consequences of sublethal IZI1551 doses to prevent unwanted proliferation and migration of melanoma metastasis. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Frangez Z, Deciphering the function of dynamic DNA epigenetic signatures as regulatory networks for melanoma progression and metastasis. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Gutta C & Rehm M Constructing and validating an autophagy-based modeling environment as a systems-biological prognostic marker for primary melanoma. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Kulms D 3D präklinische Testsysteme für die Melanomtherapie. 26th Annual Workshop on Skin Cancer (ADO), Dresden, Germany, 21 September 2016.

Lucarelli, P, De Landtsheer S, Trairatphisan P & Sauter T FALCON: A Fast Algorthm for the Contextualisation of Logical Network Models. e: Med 2016, Kiel, Germany, 4-6 October 2016.

Mueller I, Strozyk E, Hausser A, Beissert S, Walczak H & Kulms D Caspase-8 promotes uncontrolled progression of cancer cells. Gordon Conference: “New Concepts in Cell Death Research: From Basic Mechanisms to Clinical Opportunities”, Girona, Spain, 3-8 July 2016.

Mueller I, Strozyk E, Hausser A, Beissert S, Walczak H, Daugaard M, Simon HU & Kulms D Caspase-8 promotes uncontrolled progression of cancer cells. European Cell Death Organisation Annual Conference, Barcelona, Spain, 28-30 September 2016.

Palonen K Identifying and validating a panel of master transcriptional regulators in advanced melanoma using a systems transcriptomics and histology approach. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Perez-Silva L & Kulms D Targeted melanoma therapeutics contribute to tumor relapse!? EWCD – 10th European Workshop in Cell Death, Fiuggi, Italy, 3-8 April 2016.

Perez-Silva L Predicting susceptibility to mutation specific targeted drugs using quantitative modeling approaches in malignant melanoma. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Podder B Understanding the umpact of necroptosis inhibitors on cell death resistance of malignant melanoma. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Rehm M Achievements and challenges in translational systems biology and systems medicine. CASyM/SysMedIBD workshop: European Systems Medicine – Are we there yet?, Brussels, Belgium, 16 February 2016.

Rehm M Systems medicine strategies in colorectal cancer. ZPM Annual Conference, Hegne, Germany, April 2016.

Rehm M The apoptosis execution network and chemotherapy responsiveness – avenues for systems medicine applications. 9th Swiss Apoptosis Meeting, Bern, Switzerland, 8-9 September 2016.

Rehm M A stepwise integrated approach to personalized risk predictions in stage III colorectal cancer building on tumor apoptosis competency. European Cell Death Organisation Annual Conference, Barcelona, Spain, 28-30 September 2016.

Rehm M MEL-PLEX – European Translational Systems Biology Training. European Association for Systems Medicine (EASyM), Berlin, Germany, 26-28 October 2016.

Rehm M The apoptosis execution network and chemotherapy responsiveness – avenues for systems medicine applications. European Association for Systems Medicine (EASyM), Berlin, Germany, 26-28 October 2016.

Rehm M Cell Death Signaling – from experimentation to innovative applications. German Excellence Cluster “Simulation Technology” Colloquium Series, Stuttgart, Germany, November 2016.

Rehm M Choice cuts of death. Biochemistry Seminar series University of Tubingen, Germany, December 2016.

Rozanc J Identifying phosphoprotein and cytokine patterns indicative of responsiveness to targeted therapy for melanoma. Invited seminar at National Technical University of Athens, Greece, 20 May 2016.

Rozanc J Identification of predictive phosphor-signatures for targeted therapy in melanoma. Summer school “Anglo-German Research Training Initiative” London, UK, 18-22 July 2016.

Rufo N Systems analysis of immunogenic cell death (ICD) in melanoma to evaluate ICD signatures as prognostic or predictive markers of treatment responsiveness. Summer School “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Simon HU Autophagy and cancer. 15th International Summer School, University of Bern, Switzerland, 7-9 August 2016.

Simon HU Autophagy in health and disease. Swiss Apoptosis Meeting, Bern, Switzerland, 7-9 August 2016.

Tsur N Predicting responses to immunotherapy in metastatic by melanoma by personalized mathematical models. Summer school “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.

Vetma V Examining the efficacy of Dacarbazine and Birinapant combination treatment in melanoma cell lines.Thesis in 3″, RCSI Research Day, Dublin Ireland, 16 February 2016.

 Vetma V, Kulms D & Rehm M Development and validation of tools that predict cell death induced by the 2nd generation TRAIL receptor ligand. Summer School “Anglo-German Research Training Initiative”, London, UK, 18-22 July 2016.


 

 

2015

POSTERS:

Albrecht M & Sauter T Simulation tool mimics the underlying processes in a 3D organotypic skin-melanoma spheroid model and allows for fast in silico pre-testing of agents. 12th International Congress of the Society for Melanoma Research, San Francisco, USA, 18-21 November 2015.

Bodemeyer V, Cianfanelli V, DeZio D & Cecconi F Understanding the role of AMBRA-1-based signalling in melanoma development. MoMeD Summer School, Copenhagen, Denmark, 11-12 June 2015.

Bosisio FM, van Baren N, Wouters J, Stas M & van den Oord JJ  Significance of plasma cells in melanoma. Oncoforum, Leuven, Belgium, 05 June 2015.

Bosisio FM, Mercier M, Wilmott J, van Baren N, Wouters J, Scolyer R, Stas M & van den Oord JJ Significance of plasma cells in melanoma. 12th International Congress of the Society for Melanoma Research, San Francisco, USA, 18-21 November 2015.

Chiquero-Leon E, Rauch N, Romano D, Kolch W & Rauch J Regulation of the human Hippo/MST2 pathway in Raf inhibitor mediated resistant melanoma. UCD Conway Festival of Research & Innovation, Dublin, Ireland, 09-10 September 2015.

De Landtsheer S, Trairatphisan P & Sauter T Probabilistic Boolean networks as a tool to study melanoma signalling pathways. 12th International Congress of the Society for Melanoma Research, San Francisco, USA, 18-21 November 2015.

Lucarelli P, De Landtsheer S, Trairatphisan P & Sauter T Analysis of the TRAIL-induced apoptosis and ERK-MAPK signal transduction pathways in cancer cell lines by a probabilistic Boolean network approach. e:Med 2015, Heidelberg, Germany, 26-28 October 2015.

Vetma V & Rehm M Examining the effectiveness of Dacarbazine and Birinapant combination treatment in melanoma cell lines. 1st Bilateral Research Interaction Symposium – Cell Biology of Human Disease: From Molecular Mechanisms to Applications, Stuttgart, Germany, 14-16 October 2015.

 Published abstracts:

Albrecht M, Kulms D & Sauter T Simulation tool mimics the underlying processes I a 3D organotypic skin-melanoma spheroid model and allows for fast on silico pre-testing of agents. Pigment Cell & Melanoma Res doi: 10.1111/pcmr.12419. Link here.

Niessner H, Wanke I, Sinnberg T, Westphal D, Praetorius C, Schittek B, Beisert S, Kulms D, Garbe C, Meier F Effects of BRAFV600 inhibitors on endoplasmatic reticulum stress and sensitivity of NRas-mutated melanoma cells to different MEK inhibitors. Pigment Cell & Melanoma Res doi: 10.1111/pcmr.12419.

Westphal D, Niessner H, Schmitz J, Schmid A, Sinnberg T, Tabatabai G, Weide B, Garbe C, De Fend LQ, Mai M, Beissert S, Kulms D, Schackert G, Muders M, Meinhardt M, Baretton G, Pilcher B, Meier F The IGF-1R-PI3K-AKT pathway – a therapeutic target in melanoma brain metastases? Pigment Cell & Melanoma Res doi: 10.1111/pcmr.12419.

TALKS:

Agostinis P Unfolding new functions of PERK beyond the UPR. EMBO Workshop on “Mitochondria, Apoptosis & Cancer” (MAC’15), Frankfurt, Germany, 10-12 September 2015.

Agostinis P The PERKs of immunogenic cancer cell death. ICDS Conference “Implementations of knowledge of cell death”, Prague, Czech Republic, 28-30 May 2015

Agostinis P ER Stress and Calreticulin in immunogenic cell death. Invited seminar at the Duve Institute, Brussels, Belgium, 22 May 2015.

Agostinis P Unfolding the complexities of ER chaperones in health and disease. 11th International Calreticulin Workshop, “Unfolding the complexities of ER Chaperones in health and disease, New York University (NYU) School of Medicine, New York , USA, 08-15 May 2015.

Aparicio I Innovation and perspectives for doctoral training. 1st Bilateral Research Interaction Symposium. Cell Biology of Human Disease: From Molecular Mechanisms to Applications, Stuttgart, Germany, 14-16 October 2015.

Bosisio FM, van Baren N, Wouters J, Stas M & van den Oord J Significance of plasma cells in melanoma. Belgiam Week of Pathology, Ghent, Belgium, 21-24 October 2015.

Bosisio FM, van Baren N, Wouters J, Stas M & van den Oord J Significance of plasma cells in melanoma. European Congress of Pathology, Belgrade, Serbia, 05-09 September 2015.

Cecconi F Autophagy upstream regulations: of pulse, coordination and efficiency. 4th Annual Nordic Autophagy Meeting, Helsinki, Finland, 05-07 June 2015.

Gallagher W Translational melanoma research in Ireland: an update. Irish Melanoma Forum, Dublin, Ireland, 4 December 2015.

Hirschenhahn E Data-driven systems modelling to prognosticate cancer recurrence and progression. 1st Bilateral Research Interaction Symposium – Cell Biology of Human Disease: From Molecular Mechanisms to Applications, Stuttgart, Germany, 14-16 October 2015.

Kulms D The p53 and NFkB cross-talk: Friends or Foes? 23rd Conference of the European Cell Death Organization,‘Death pathways and beyond’, Geneva, Switzerland, 07-10 October 2015.

Kulms D The p53 and NFkB cross-talk: Friends or Foes? 9th Tuscany Retreat on Cancer Research and Apoptosis, “Genetic profiling, resistance mechanism and novel treatment concepts in cancer”, Sarteano-Siena, Italy, 01-08 August 2015.

Kulms D Caspase-8: Death or survival?!. Cell Death and Disease Workshop, Villa Vigoni, Italy, 24-27 June 2015.

Kulms D Three dimensional melanoma treatment using the death ligand TRAIL15th International TNF conference in Ghent, Belgium: 20-23 May, 2015

Kulms D Identification of therapeutic targets in skin cancer using experimental and mathematical modeling approaches. Invited Seminar, University of Luxembourg, 17 February 2015.

Rauch N, McCann B, Chiquero-Leon E, Santra T, Baljuls A, Pilkington R, Kennedy S, von Kriegsheim A, Rauch J & Kolch W Partners in crime – Signalling through Raf heterodimers. 4th International Conference on Analytical Proteomics, Caparica, Portugal, 07-09 September 2015.

Sauter T & Aparicio I Overview of MEL-PLEX ETN – Life sciences parallel session. Future of the Doctorate (EU Presidency Conference) Riga, Latvia, 28-29 May 2015.

Rehm M From cancer cell biology to systems medicine applications. Invited Seminar, German-Austrian-Swiss Research Group FOR-2036, Obergurgl, Austria, April 2015.

Rehm M From cancer systems biology to systems medicine. Invited Seminar, Guangzhou Medical University, Guangzhou City, China, March 2015.

Rehm M Cell death signalling – mechanistic insight and translational applications. Invited Seminar, Queens University, Belfast, UK, January 2015.

Westphal D, Niessner H, Schmitz J, Schmid A, Sinnberg T, Tabatai G, Weide B, Garbe C, De Fend LQ, Mai M, Beissert S, Kulms D, Schackert G, Muders M, Meinhardt M, Baretton G, Pilcher B & Meier F The IGF-1R-PI3K-AKT pathway – a therapeutic target in melanoma brain metastases? 12th International Meeting of the Society for Melanoma Research, San Francisco, USA, 18-21 November 2015

2014

TALKS:

Rehm M From cancer cell biology to systems medicine applications. Invited Seminar, Charite University Clinics, Berlin, Germany, December 2014.

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